A Mainframe is a giant room-sized machine used for big computing jobs. Mainframe computers can communicate with several users simultaneously. They are used by banks. For example, when you make a deposit, a mainframe does the transaction.
A Microcomputer is basically a personal computer. It is based on a microprocessor and is meant to be used by one person at a time, unlike mainframes. They cannot perform functions and calculations as great as the mainframe can.
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